WebNov 20, 2024 · さらに、網羅的な遺伝子発現を調べることで、AtoMがFoxM1と呼ばれる転写因子により部分的に制御されていることが示され、FoxM1の阻害薬がマウスにおいても、関節リウマチ患者の関節液から採取した細胞においても、破骨細胞への分化を阻害することが明らかとなった。 WebDec 13, 2024 · Macrophages mediate vagus-induced hepatic FoxM1 activation. a (Upper panels) Representative images of liver sections immunostained for F4/80 from mice 24 h after receiving control and...
Alteration of FOXM1 expression and macrophage polarization in ...
WebNational Center for Biotechnology Information WebMay 7, 2024 · In this regard, FOXM1 has been implicated in both recruitment and functional modulation of macrophages in a butylated hydroxytoluene-induced model of lung inflammation . Since M2 macrophages promote tissue fibrosis in part via elaboration of TGF-β ( 67 ), it is possible that the inhibitory effects of Sio A on lung TGF-β levels may also … エステルゴム 観光
Disrupting LXRα phosphorylation promotes FoxM1 expression and …
WebAug 23, 2012 · Ablation of Foxm1 in macrophages reduced the number and size of lung tumors in macFoxm1 (-/-) mice. Decreased tumorigenesis was associated with … Histological examination confirmed the reduced size of lung tumors in macFoxm1−/− mice and showed that these tumors showed morphological characteristics of lung adenomas (Figure 2b). The number of Ki-67-positive tumor cells was significantly decreased in the macFoxm1−/− lungs compared with control … See more Previous studies demonstrated that BHT promotes lung tumorigenesis by inducing pulmonary inflammation and macrophage infiltration into the lung tissue (Malkinson et al., 1997; Blaine et … See more Foxm1 protein was not detected in quiescent lungs by immunohistochemistry, but was dramatically induced after BHT-induced lung injury in both alveolar macrophages and respiratory epithelial cells of control … See more Expression of chemokine and cytokine receptors critical for macrophage migration was examined in pulmonary macrophages and their monocytic precursors isolated from BHT-treated lungs. Decreased … See more The observed decrease in the number of macrophages in the macFoxm1−/− lung tumors could be the result of impaired macrophage migration. Macrophages were isolated from macFoxm1−/− or control mice, and in … See more WebNov 3, 2024 · Macrophages were exposed to IL-4 to induce M2 phenotype polarization. Ectopic expression or knockdown of FOXM1 was performed to observe collagen deposition, angiogenesis, the proliferation and migration of HDF, as well as macrophage polarization. Results FOXM1 was lowly expressed in the wound tissue of DFU rats. panel amicos