Fth1 aging
WebJul 15, 2024 · Genes were classified as significant under a false-discovery rate (FDR) threshold of 0.01 and an age coefficient threshold of 0.005 (corresponding to an approximately 10%-fold change). WebNov 11, 2024 · Nature Aging - The authors demonstrate that release of peroxidated lipids from mouse neurons following ablation of the small GTPase ARF1 leads to activation of a neurotoxic microglial NLRP3 pathway...
Fth1 aging
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WebMay 19, 2024 · Elevated FTH1 mRNA levels were correlated with worse prognosis of RCC patients. Cox multivariate survival analysis indicated that age, stage, and M stage were … WebNational Center for Biotechnology Information
WebAssigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein … WebThe gene signature designed from AML patients overexpressing FTH1 revealed a significant enrichment in genes of the immune and inflammatory response including Nf-KB pathway, oxidative stress, or iron pathways. This gene signature was enriched in cytarabine-resistant AML cells in a patient-derived xenograft model.
WebMar 5, 2024 · D 5mC antibody enriched FTH1 and FTL mRNA, whereas NSUN5 knockdown reduced 5mC levels in FTH1 and FTL mRNA, as determined by RNA immunoprecipitation (RIP) and reverse transcription-quantitative ... WebSep 16, 2024 · Protein LLPS refers to the concentration of uniformly dissolved proteins into liquid-like condensates, which can further transition into less dynamic material states such as gels or solid fibers ().LLPS can triage protein cargoes for macroautophagic degradation ().To investigate whether ferritin particles undergo LLPS, Ohshima et al. observed mGFP …
WebSep 22, 2024 · FTH1 silencing promoted cell growth and mammosphere formation, increased c-MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c-MYC expression, and sensitized cancer cells to chemotherapy; silencing of c-MYC recapitulated the effects of FTH1 …
WebNov 2, 2024 · How Rapamycin may help combat aging; How Metformin seems to slow down aging; What NAD+ is and how increasing it may help us age slower; Perhaps the most … drakor sikopatWebMar 24, 2024 · A host of well-established Nrf2 target genes, including SLC7A11, FTH1 / FTL, SLC48A1, GPX4, ... Overall, the gradual loss of Nrf2 with aging is thought to increase susceptibility to ferroptosis, which has been recently demonstrated to play critical roles in the pathogenesis of PD, AD, ... drakorsiaWebFeb 2, 2024 · The detrimental effect of FTH1 downregulation on cardiac function is supported by a recent report showing that mice lacking FTH1 in cardiomyocytes increased oxidative stress, resulting in mild cardiac dysfunction upon aging (Fang et al., 2024). radmila smiljanic operaWebferritin heavy chain Antibody (B-12) is a mouse monoclonal IgG 2a κ ferritin heavy chain antibody, cited in 58 publications, provided at 200 µg/ml raised against amino acids 131-183 of ferritin heavy chain of human origin drakor seru 2023WebSep 22, 2024 · Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple-negative subtype (triple … radmila stojanovic velika planaWebApr 3, 2024 · To further examine whether iron overload is caused by ferritinophagy, we assessed the effect of Sch B on the expression of FTH1 in cultured LX2 cells. The protein expression of FTH1 was increased by Sch B (Figure 4(e)). Additionally, Sch B promoted the binding of NCOA4 to FTH1 in vitro (Figure 4(f)). Collectively, these data suggested that … drakor smaWebSep 1, 2024 · Analysis of ferroptosis revealed that KD can inhibit iron dyshomeostasis by down-regulating the expression of TfR1 and DMT1 and up-regulating the expression of FTH1, FPN1. Meanwhile, KD alleviated oxidative stress with elevated xCT/GPX4 axis, FSP1 and reduced MDA. In addition, KD could promote neuronal repair by enhancing BDNF … radmila stupar