2024 N n-dimethylaniline monooxygenase activity

N n-dimethylaniline monooxygenase activity

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August undefined, 2024

Webflavin containing dimethylaniline monoxygenase 3: RGD ID: 619761: Description: Enables N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in xenobiotic metabolic process. Located in intracellular membrane-bounded organelle. WebAcute inhalation exposure to N,N-dimethylaniline has resulted in effects on the CNS and circulatory system, with headache, cyanosis, dizziness, labored breathing, paralysis, and …

856581 - Gene ResultFMO1 N,N-dimethylaniline monooxygenase []

http://ic4r.org/genes/IC4R-OSJ01G108100 WebN -oxide and S -oxide formation represent the major FMO-mediated reactions In contrast to most CYP isoenzymes, the FMOs bind and activate molecular oxygen before the substrate … sharon harper health canada

Flavin-containing monooxygenase 3 - Wikipedia

WebProbable flavin-containing monooxygenase 1 Gene FMO1 Status UniProtKB reviewed (Swiss-Prot) Organism Arabidopsis thaliana (Mouse-ear cress) Amino acids 530 Protein existence Evidence at transcript level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function WebAbstract Human liver microsomal flavin-containing monooxygenase activity has been studied using dimethylaniline N-oxidation and thiobenzamide S-oxidation. Except for one … WebDimethylaniline [N,N-Dimethylaniline], N,N-Dimethylbenzeneamine, N,N-Dimethylphenylamine [Note: Also known as Dimethylaniline which is a correct synonym … population us

Dimethylaniline Monooxygenase - an overview

WebLiver microsomal benzydamine N-oxygenation was inhibited by dimethyl sulfoxide and methimazole, whereas N-demethylation was inhibited by quinidine. High benzydamine N-oxygenation activities of recombinant human FMO1 and FMO3 and human kidney microsomes were observed at pH 8.4, whereas N-demethylation by cytochrome P450 2D6 … population us 1940WebMetabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. population us 1950

"WebJan 14, 2013 · It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773). Pfam Domain Function FMO-like ( PF00743) … " - N n-dimethylaniline monooxygenase activity

N n-dimethylaniline monooxygenase activity

WebPredicted to enable N,N-dimethylaniline monooxygenase activity and aldehyde oxidase activity. Involved in regulation of cholesterol metabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in bladder. Orthologous to human FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome … WebN,N-dimethylaniline monooxygenase activity Gene Ontology Term (GO:0004499) Home Genes Human Disease Expression Recombinases Function Strains / SNPs Homology …

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WebFeb 15, 2024 · Flavin monooxygenase-like Catalytic Activity (EC) Experimental Evidence - Predictions / Assertions H (+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP (+) ( 1.14.13.8 ) Summaries Gene Model and Products Expression Data Alleles, Insertions, Transgenic Constructs, and Aberrations Variants … WebJan 14, 2013 · 1.14.13.8. H (+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP (+) A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines. Is distinct from other …

WebHuman data: N,N-Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect -- notably, methemoglobinemia [Clayton and … WebJan 14, 2013 · NX_Q99518 - FMO2 - Dimethylaniline monooxygenase [N-oxide-forming] 2 - Function. Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole.

WebThe flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. WebJan 10, 2024 · N,N-dimethylaniline monooxygenase activity Gene Ontology Term (GO:0004499) Home Genes Human Disease Expression Recombinases Function Strains / …

WebSep 27, 2024 · The AAA+ protein, Skd3 (human CLPB), solubilizes proteins in the mitochondrial intermembrane space, which is critical for human health. Skd3 variants with …

WebNov 4, 2024 · Title: The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance. FMO1 and NUDT7 are … sharon harper obituaryWebJan 14, 2013 · General Function. Nadp binding. Specific Function. This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Pfam Domain Function. FMO-like ( PF00743) Transmembrane Regions. Not Available. sharon harper mnWebGO:0004499 N,N-dimethylaniline monooxygenase activity; Reaction participants Show >> << Hide. ... enhanced the MPTP N-oxygenation activity by 51%, while methimazole, thiobenzamide and alpha-naphthylthiourea, alternate substrates of FMO, inhibited it by 27.4, 68.0 and 59.2%, respectively. The results indicate that MPTP is efficiently N ... sharon harker beaufort ncWebAbstract Human liver microsomal flavin-containing monooxygenase activity has been studied using dimethylaniline N-oxidation and thiobenzamide S-oxidation. Except for one subject, the capacity of human liver microsomes to mediate these reactions were markedly increased at pH 8.4 compared to pH 7.4. population us territoriesWebN,N-dimethylaniline monooxygenase activity trimethylamine monooxygenase activity Process metabolic process oxidation reduction Cellular Location Endoplasmic reticulum membrane Microsome membrane Gene Properties Chromosome Location 1 Locus 1q24.3 SNPs FMO3 Gene Sequence >1599 bp … population uzbekistan country 2020WebN,N-Dimethylaniline is an organic compound. It is a colorless to pale yellow liquid with a pungent odor at room temperature and pressure. N,N-Dimethylaniline is widely used in the chemical industry for dyes, pharmaceuticals, pesticides, rubber, plastics, and as an intermediate and reagent for reactions. It can also be used as a catalyst and ... population us virgin islands 2020WebDimethylaniline Monooxygenase The FMOs (EC 1.14.13.8) are a family of microsomal, NADPH-dependent enzymes that catalyze the oxygenation of nucleophilic nitrogen-, sulfur … population utah counties